{"id":10034,"date":"2023-06-08T22:32:04","date_gmt":"2023-06-08T22:32:04","guid":{"rendered":"https:\/\/cogrx.wpengine.com\/?page_id=10034"},"modified":"2025-01-08T17:23:00","modified_gmt":"2025-01-08T22:23:00","slug":"alzheimers-disease-moa","status":"publish","type":"page","link":"https:\/\/cogrx.com\/pipeline\/alzheimers-disease-moa\/","title":{"rendered":"Alzheimer&#8217;s Disease"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"10034\" class=\"elementor elementor-10034\" data-elementor-settings=\"{&quot;ha_cmc_init_switcher&quot;:&quot;no&quot;}\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-bf8b356 elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"bf8b356\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;background_background&quot;:&quot;classic&quot;,&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5e7389e\" data-id=\"5e7389e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-61d45cd elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"61d45cd\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-e242787\" data-id=\"e242787\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ed80eb1 elementor-widget elementor-widget-text-editor\" data-id=\"ed80eb1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tAge-related Buildup of Toxic Proteins\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d04bc8b elementor-widget elementor-widget-text-editor\" data-id=\"d04bc8b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Alzheimer\u2019s disease is believed to be caused, in part, by the age-related buildup of proteins including amyloid beta (A\u03b2).<\/p><p>Under normal conditions, these proteins are removed from the brain before they accumulate and aggregate into more toxic forms, called oligomers. When this function is disrupted, the formation of toxic oligomers can lead to neurodegenerative disorders such as Alzheimer\u2019s disease. These toxic oligomers bind to synapses and cause a cascade of damage resulting eventually in the loss of neurons and cognitive dysfunction.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-7ab322b\" data-id=\"7ab322b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a9a228c elementor-widget elementor-widget-image\" data-id=\"a9a228c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"549\" height=\"419\" src=\"https:\/\/cogrx.com\/wp-content\/uploads\/2021\/03\/alzheimers-disease-tile-neurons-orange-corner.png\" class=\"attachment-full size-full wp-image-5782\" alt=\"\" srcset=\"https:\/\/cogrx.com\/wp-content\/uploads\/2021\/03\/alzheimers-disease-tile-neurons-orange-corner.png 549w, https:\/\/cogrx.com\/wp-content\/uploads\/2021\/03\/alzheimers-disease-tile-neurons-orange-corner-300x229.png 300w\" sizes=\"(max-width: 549px) 100vw, 549px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-fbe762a elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"fbe762a\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-edff59e\" data-id=\"edff59e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-edc399f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"edc399f\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-502910a\" data-id=\"502910a\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3348a59 elementor-widget elementor-widget-text-editor\" data-id=\"3348a59\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tA Unique Approach to Treating Alzheimer&#8217;s Disease\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-039a333 elementor-widget elementor-widget-text-editor\" data-id=\"039a333\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>In Alzheimer\u2019s disease, evidence suggests that A\u03b2 oligomers are toxic to synapses in the brain. When oligomers bind to neurons, they damage synapses, which are the points of communication between neurons. Over time, the recurring damage to synapses leads to loss of neurons and cognitive decline.<\/p><p>Many efforts in drug development for Alzheimer\u2019s disease have focused on removing A\u03b2 plaques that have accumulated from the brain. We believe that preventing A\u03b2 oligomers from binding to the synapse, where their toxic effects initiate damage, is a promising neuroprotective approach acting earlier in the amyloid cascade.<\/p><p>Cognition Therapeutics is developing zervimesine (also CT1812), an oral, brain-penetrant, small molecule therapeutic, which has been shown to protect neurons and synapses by preventing the binding of toxic oligomers. We believe that the results of our clinical trials demonstrate that zervimesine acts as a neuroprotective agent both by shielding neurons and synapses from oligomer binding and by preventing oligomers from attaching to synapses in the first place. Zervimesine may help mitigate the neurotoxic effects, slowing cognitive decline and progression of Alzheimer&#8217;s disease.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-9acc800 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9acc800\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-933f62e\" data-id=\"933f62e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0837500 elementor-widget elementor-widget-text-editor\" data-id=\"0837500\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tZervimesine : A Team Player\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-708d09d elementor-widget elementor-widget-text-editor\" data-id=\"708d09d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Zervimesine has the potential to work in synergy with recently approved monoclonal antibody treatments. Due to its unique mechanism of action and favorable safety profile, zervimesine has the potential to complement treatments that remove plaques or impact other disease mechanisms by playing the vital role of synaptic protector.<\/p><p>Watch our mechanism of action video to learn more. \u00bb<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-d8c90d4\" data-id=\"d8c90d4\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-388e927 elementor-widget elementor-widget-menu-anchor\" data-id=\"388e927\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-menu-anchor\" id=\"moa-video\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2a2835e elementor-widget elementor-widget-premium-addon-video-box\" data-id=\"2a2835e\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;premium_video_box_video_type&quot;:&quot;vimeo&quot;,&quot;video_lightbox_style&quot;:&quot;prettyphoto&quot;,&quot;aspect_ratio&quot;:&quot;169&quot;}\" data-widget_type=\"premium-addon-video-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\n\n\t\t\n\t\t\t\t\t<div data-lightbox=\"{&quot;type&quot;:&quot;prettyphoto&quot;,&quot;theme&quot;:&quot;dark_rounded&quot;}\" id=\"premium-video-box-container-2a2835e\" class=\"premium-video-box-container\" data-overlay=\"true\" data-type=\"vimeo\" data-thumbnail=\"1\" data-hover=\"none\">\n\t\t\t\t<div  >\n\t\t\t\t\t\t\t\n\t\t\t\t\t<div class=\"premium-video-box-inner-wrap\" data-video-animation=\" animated-\" data-delay-animation=\"\">\n\t\t\t\t\t\t<div class=\"premium-video-box-video-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"premium-vid-lightbox-container\" data-rel=\"prettyPhoto[premium-videobox-2a2835e]\" href=\"https:\/\/player.vimeo.com\/video\/800999561?rel=0&amp;muted=0&amp;loop=0&amp;controls=1&amp;playsinline=0&amp;color=&amp;autopause=0&amp;#t=&amp;autoplay=1&amp;iframe=true\"><\/a>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div style=\"background-image:url(&#039;https:\/\/cogrx.wpengine.com\/wp-content\/uploads\/2023\/04\/MoA-Video-2023-thumbnail.png&#039;)\" class=\"premium-video-box-image-container none\"><\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-ha-element-link=\"{&quot;url&quot;:&quot;#elementor-action%3Aaction%3Dpopup%3Aopen%26settings%3DeyJpZCI6Ijk4NDciLCJ0b2dnbGUiOmZhbHNlfQ%3D%3D&quot;,&quot;is_external&quot;:&quot;&quot;,&quot;nofollow&quot;:&quot;&quot;}\" style=\"cursor: pointer\" class=\"elementor-element elementor-element-e4bb88a elementor-widget elementor-widget-image\" data-id=\"e4bb88a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/cogrx.wpengine.com\/wp-content\/uploads\/2023\/03\/MoA-Video-2023-thumbnail.png\" title=\"\" alt=\"\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-0b273e5 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"0b273e5\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-5ec6cef\" data-id=\"5ec6cef\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8f256dd elementor-widget elementor-widget-toggle\" data-id=\"8f256dd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1501\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-1501\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-chevron-down\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-chevron-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Select Completed Studies<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1501\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-1501\"><span style=\"font-weight: 600;\">SHINE COG0201 study:<\/span>\n<ul>\n \t<li>Complete with results: 153 adults with mild-to-moderate Alzheimer&#8217;s disease were randomized to receive one of two doses of zervimesine or placebo.<\/li>\n \t<li>Supported by appx $31 million in grant awards from the National Institute on Aging (NIA) of the National Institutes of Health (NIH).<\/li>\n \t<li>On July 29, 2024, a webcast was held to review findings from the SHINE study. Click <a href=\"https:\/\/ir.cogrx.com\/events\/shine-phase-2-results-webcast\/\" target=\"_blank\" rel=\"noopener\">here <\/a>for the archive.<\/li>\n \t<li>Cognition conducted a second call on October 30, 2024 to review findings of a pre-specified analysis of SHINE subgroups defined by their baseline plasma p-tau217 concentrations.\u00a0An archive of this call and supporting materials may be found\u00a0<a href=\"https:\/\/ir.cogrx.com\/events\/ctad-presentation-data-review\/\" target=\"_blank\" rel=\"noopener\">here<\/a>.<\/li>\n \t<li>For more information, please visit clinicatrials.gov and reference <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT03507790\" target=\"_blank\" rel=\"noopener\">NCT03507790<\/a>.<\/li>\n<\/ul>\n<span style=\"font-weight: 600;\">SEQUEL COG0202 study:<\/span>\n<ul>\n \t<li>Assessed disease-modification as a function of synapse function as measured by qualitative EEG.<\/li>\n \t<li>Topline results showed improvements in global measures of brain activity.<\/li>\n \t<li>For more information, please visit clinicatrials.gov and reference\u00a0<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT04735536\" target=\"_blank\" rel=\"noopener\">NCT04735536<\/a>.<\/li>\n \t<li>Background information on qEEG and a summary of topline results maybe found <a href=\"https:\/\/cogrx.com\/clinical-trials\/sequel-phase-2-ct1812-eeg-study\/\">here<\/a>.<\/li>\n<\/ul>\n<span style=\"font-weight: 600;\"> SNAP COG0104 study:<\/span>\n<ul>\n \t<li>Assessed target engagement vis-a-vis displacement of A\u03b2 oligomers.<\/li>\n \t<li>For more information, please visit clinicaltrials.gov and reference\u00a0<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT03522129\" target=\"_blank\" rel=\"noopener\">NCT03522129<\/a>.<\/li>\n<\/ul>\n<span style=\"font-weight: 600;\">SPARC COG0105 study:<\/span>\n<ul>\n \t<li>Assessed disease-modification as a measure of synapse density with PET imaging.<\/li>\n \t<li>For more information, please visit clinicaltrials.gov and reference\u00a0<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT03493282\" target=\"_blank\" rel=\"noopener\">NCT03493282<\/a>.<\/li>\n<\/ul>\n<span style=\"font-weight: 600;\">Phase 1b\/2a COG0102 study:<\/span>\n<ul>\n \t<li>Zervimesine was generally safe and tolerated in patients with mild-to-moderate Alzheimer\u2019s disease.<\/li>\n \t<li>All adverse events were mild or moderate; there were no serious adverse events.<\/li>\n \t<li>Zervimesine achieved CSF concentrations greater than 80 percent estimated brain receptor occupancy, a level previously demonstrated in preclinical studies to be the minimum efficacious dose.<\/li>\n \t<li>Protein biomarkers associated with Alzheimer\u2019s disease changed differentially in zervimesine-treated vs. placebo patients.<\/li>\n \t<li>For more information, please visit clinicaltrials.gov and reference\u00a0<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT02907567\" target=\"_blank\" rel=\"noopener\">NCT02907567<\/a>.<\/li>\n<\/ul><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1502\" class=\"elementor-tab-title\" data-tab=\"2\" role=\"button\" aria-controls=\"elementor-tab-content-1502\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-chevron-down\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-chevron-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Select Ongoing Studies<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1502\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"region\" aria-labelledby=\"elementor-tab-title-1502\"><p><span style=\"font-size: 16px; font-weight: 600;\">START COG0203 study:<\/span><\/p><ul><li>Phase 2 study in early Alzheimer\u2019s disease in collaboration with the Alzheimer\u2019s Clinical Trials Consortium (ACTC).<\/li><li>Target enrollment: 540<\/li><li>Supported by a $81 million grant from the National Institute on Aging (NIA) of the National Institutes of Health (NIH).<\/li><li>For more information, please visit <a href=\"https:\/\/start-study.org\/\" target=\"_blank\" rel=\"noopener\">start-study.org<\/a>\u00a0or clinicatrials.gov and reference <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05531656\" target=\"_blank\" rel=\"noopener\">NCT05531656<\/a>.<\/li><\/ul><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Age-related Buildup of Toxic Proteins Alzheimer\u2019s disease is believed to be caused, in part, by the age-related buildup of proteins including amyloid beta (A\u03b2). Under normal conditions, these proteins are removed from the brain before they accumulate and aggregate into more toxic forms, called oligomers. When this function is disrupted, the formation of toxic oligomers [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":5745,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_theme","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-10034","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/cogrx.com\/wp-json\/wp\/v2\/pages\/10034","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cogrx.com\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/cogrx.com\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/cogrx.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cogrx.com\/wp-json\/wp\/v2\/comments?post=10034"}],"version-history":[{"count":0,"href":"https:\/\/cogrx.com\/wp-json\/wp\/v2\/pages\/10034\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/cogrx.com\/wp-json\/wp\/v2\/pages\/5745"}],"wp:attachment":[{"href":"https:\/\/cogrx.com\/wp-json\/wp\/v2\/media?parent=10034"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}