{"id":12960,"date":"2024-11-06T17:08:27","date_gmt":"2024-11-06T22:08:27","guid":{"rendered":"https:\/\/cogrx.com\/?page_id=12960"},"modified":"2026-03-10T09:58:05","modified_gmt":"2026-03-10T13:58:05","slug":"publications","status":"publish","type":"page","link":"https:\/\/cogrx.com\/pipeline\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"12960\" class=\"elementor elementor-12960\" data-elementor-settings=\"{&quot;ha_cmc_init_switcher&quot;:&quot;no&quot;}\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-bf8b356 elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"bf8b356\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;background_background&quot;:&quot;classic&quot;,&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5e7389e\" data-id=\"5e7389e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-40f337b elementor-widget elementor-widget-shortcode\" data-id=\"40f337b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"shortcode.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-shortcode\"><form data-sf-form-id='12979' data-is-rtl='0' data-maintain-state='' data-results-url='https:\/\/cogrx.com\/pipeline\/publications\/' data-ajax-url='https:\/\/cogrx.com\/?sfid=12979&amp;sf_action=get_data&amp;sf_data=all' data-ajax-form-url='https:\/\/cogrx.com\/?sfid=12979&amp;sf_action=get_data&amp;sf_data=form' data-display-result-method='shortcode' data-use-history-api='1' data-template-loaded='0' data-lang-code='en' data-ajax='1' data-ajax-data-type='json' data-ajax-links-selector='.pagination a' data-ajax-target='#search-filter-results-12979' data-ajax-pagination-type='normal' data-update-ajax-url='1' data-only-results-ajax='1' data-scroll-to-pos='0' data-init-paged='1' data-auto-update='1' data-auto-count='1' data-auto-count-refresh-mode='1' action='https:\/\/cogrx.com\/pipeline\/publications\/' method='post' class='searchandfilter' id='search-filter-form-12979' autocomplete='off' data-instance-count='1'><ul><li class=\"sf-field-taxonomy-disease_indication\" data-sf-field-name=\"_sft_disease_indication\" data-sf-field-type=\"taxonomy\" data-sf-field-input-type=\"select\">\t\t<label>\n\t\t\t\t   \t\t\t<span class=\"screen-reader-text\">Choose Disease Indication<\/span>\n\t\t\t\t\t\t\t\t<select name=\"_sft_disease_indication[]\" class=\"sf-input-select\" title=\"Choose Disease Indication\">\n\t\t\t\t\t\t  \t\t\t<option class=\"sf-level-0 sf-item-0 sf-option-active\" selected=\"selected\" data-sf-count=\"0\" data-sf-depth=\"0\" value=\"\">All Disease Indications<\/option>\n\t\t\t\t\t\t\t\t\t\t\t<option class=\"sf-level-0 sf-item-1860\" data-sf-count=\"42\" data-sf-depth=\"0\" value=\"alzheimers-disease\">Alzheimers Disease&nbsp;&nbsp;(42)<\/option>\n\t\t\t\t\t\t\t\t\t\t\t<option class=\"sf-level-0 sf-item-1861\" data-sf-count=\"10\" data-sf-depth=\"0\" value=\"dementia-with-lewy-bodies\">Dementia with Lewy Bodies&nbsp;&nbsp;(10)<\/option>\n\t\t\t\t\t\t\t\t\t\t\t<option class=\"sf-level-0 sf-item-1862\" data-sf-count=\"9\" data-sf-depth=\"0\" value=\"geographic-atrophy\">Geographic Atrophy&nbsp;&nbsp;(9)<\/option>\n\t\t\t\t\t\t\t\t\t\t\t<\/select><\/label>\t\t\t\t\t\t\t\t\t\t<\/li><li class=\"sf-field-taxonomy-resource_type\" data-sf-field-name=\"_sft_resource_type\" data-sf-field-type=\"taxonomy\" data-sf-field-input-type=\"select\">\t\t<label>\n\t\t\t\t   \t\t\t<span class=\"screen-reader-text\">Choose Resource Type<\/span>\n\t\t\t\t\t\t\t\t<select name=\"_sft_resource_type[]\" class=\"sf-input-select\" title=\"Choose Resource Type\">\n\t\t\t\t\t\t  \t\t\t<option class=\"sf-level-0 sf-item-0 sf-option-active\" selected=\"selected\" data-sf-count=\"0\" data-sf-depth=\"0\" value=\"\">All Resource Types<\/option>\n\t\t\t\t\t\t\t\t\t\t\t<option class=\"sf-level-0 sf-item-1855\" data-sf-count=\"26\" data-sf-depth=\"0\" value=\"manuscript\">Manuscript&nbsp;&nbsp;(26)<\/option>\n\t\t\t\t\t\t\t\t\t\t\t<option class=\"sf-level-0 sf-item-1856\" data-sf-count=\"38\" data-sf-depth=\"0\" value=\"poster\">Poster&nbsp;&nbsp;(38)<\/option>\n\t\t\t\t\t\t\t\t\t\t\t<option class=\"sf-level-0 sf-item-1857\" data-sf-count=\"5\" data-sf-depth=\"0\" value=\"scientific-slides\">Scientific Slides&nbsp;&nbsp;(5)<\/option>\n\t\t\t\t\t\t\t\t\t\t\t<\/select><\/label>\t\t\t\t\t\t\t\t\t\t<\/li><li class=\"sf-field-search\" data-sf-field-name=\"search\" data-sf-field-type=\"search\" data-sf-field-input-type=\"\">\t\t<label>\n\t\t\t\t   \t\t\t<span class=\"screen-reader-text\">Search Resources<\/span><input placeholder=\"Search \u2026\" name=\"_sf_search[]\" class=\"sf-input-text\" type=\"text\" value=\"\" title=\"Search Resources\"><\/label>\t\t<\/li><\/ul><\/form>\n<div class=\"search-filter-results\" id=\"search-filter-results-12979\">   <div class=\"pagination\">\n        <!-- Display Number of posts -->\n        <div class=\"num-posts\">Found 69 Results<br \/><\/div> \n\t<\/div> <!-- pagination close -->\n\n\t<div class='lsc-sf-container'>\n\t\t\t\t<div class='lsc-sf-item'>\n\t\t\t\t<div class=\"lsc-sf-date lsc-ir-date\">April 7, 2026 | <em>Manuscript<\/em><\/div>\n\t\t\t\t<div class=\"lsc-sf-title lsc-ir-title\"><a href=\"https:\/\/doi.org\/10.1186\/s13195-026-02025-4\" target=\"_blank\" class=\"lsc-sf-link\">Impact of zervimesine on the neuroinflammatory biomarker GFAP and related proteomic molecular correlates in plasma of participants from a phase 2 clinical trial in Alzheimer&#8217;s disease<\/a><\/div>\n\t\t\t\t<div class=\"lsc-sf-date lsc-ir-date\">Alzheimers Res Ther. 2026 Apr 6 (online ahead of print)<br> Authors: Di Caro V, Cho E, Thiel J, et al. <\/div>\n\t\t\t<\/div>\t\t\t\n\t\t\t\t\t<div class='lsc-sf-item'>\n\t\t\t\t<div class=\"lsc-sf-date lsc-ir-date\">April 6, 2026 | <em>Manuscript<\/em><\/div>\n\t\t\t\t<div class=\"lsc-sf-title lsc-ir-title\"><a href=\"https:\/\/doi.org\/10.1177\/13872877261437145\" target=\"_blank\" class=\"lsc-sf-link\">Randomized, Double-blind Study of Zervimesine in Mild-to-moderate Alzheimer&#8217;s Disease<\/a><\/div>\n\t\t\t\t<div class=\"lsc-sf-date lsc-ir-date\">J Alzheimers Dis. 2026 Apr 3 (Online ahead of print.)<br> Authors: Vijverberg EGB, Scharre DW, Woodward M, et al.<\/div>\n\t\t\t<\/div>\t\t\t\n\t\t\t\t\t<div class='lsc-sf-item'>\n\t\t\t\t<div class=\"lsc-sf-date lsc-ir-date\">March 17, 2026 | <em>Poster<\/em><\/div>\n\t\t\t\t<div class=\"lsc-sf-title lsc-ir-title\"><a href=\"https:\/\/cogrx.com\/wp-content\/uploads\/2026\/03\/Grundman_et_al-ADPD_2026-DLB_Symptom_Progression.pdf\" target=\"_blank\" class=\"lsc-sf-link\">Zervimesine Slows Progression of Symptoms in Mild-to-Moderate Dementia with Lewy Bodies<\/a><\/div>\n\t\t\t\t<div class=\"lsc-sf-date lsc-ir-date\">Poster presented at AD\/PD\u2122 2026 Alzheimer's & Parkinson's Diseases Conference; Copenhagen, Denmark<br> Authors: Grundman M, Galvin J, Iaci JF, et al.<\/div>\n\t\t\t<\/div>\t\t\t\n\t\t\t\t\t<div class='lsc-sf-item'>\n\t\t\t\t<div class=\"lsc-sf-date lsc-ir-date\">March 17, 2026 | <em>Poster<\/em><\/div>\n\t\t\t\t<div class=\"lsc-sf-title lsc-ir-title\"><a href=\"https:\/\/cogrx.com\/wp-content\/uploads\/2026\/03\/Grundman_et_al-ADPD_2026-Global_statistical_test.pdf\" target=\"_blank\" class=\"lsc-sf-link\">A Global Statistical Test Approach to Clinical Trials with Zervimesine for Dementia with Lewy Bodies<\/a><\/div>\n\t\t\t\t<div class=\"lsc-sf-date lsc-ir-date\">Poster presented at AD\/PD\u2122 2026 Alzheimer's & Parkinson's Diseases Conference; Copenhagen, Denmark<br> Authors: Grundman M, Iaci JF, Hendrix S, et al<\/div>\n\t\t\t<\/div>\t\t\t\n\t\t\t\t\t<div class='lsc-sf-item'>\n\t\t\t\t<div class=\"lsc-sf-date lsc-ir-date\">February 24, 2026 | <em>Manuscript<\/em><\/div>\n\t\t\t\t<div class=\"lsc-sf-title lsc-ir-title\"><a href=\"https:\/\/doi.org\/10.1016\/j.exer.2026.110944\" target=\"_blank\" class=\"lsc-sf-link\">Sigma-2 Receptor Modulators Alter Low-density Lipoprotein Receptor-mediated Lipid Uptake in Retinal Pigment Epithelial Cells<\/a><\/div>\n\t\t\t\t<div class=\"lsc-sf-date lsc-ir-date\">Experimental Eye Research. 267 (2026) 110944<br> Authors: Lizama BN, Reaver A, Look G, et al<\/div>\n\t\t\t<\/div>\t\t\t\n\t\t\t\t\t<div class='lsc-sf-item'>\n\t\t\t\t<div class=\"lsc-sf-date lsc-ir-date\">December 1, 2025 | <em>Poster<\/em><\/div>\n\t\t\t\t<div class=\"lsc-sf-title lsc-ir-title\"><a href=\"https:\/\/cogrx.com\/wp-content\/uploads\/2025\/12\/p009_ctad_poster_iaci_alzheimers_ph3_design.pdf\" target=\"_blank\" class=\"lsc-sf-link\">Alzheimer\u2019s Disease Pivotal Trial Design for Zervimesine Following an End-of-Phase 2 Meeting with FDA<\/a><\/div>\n\t\t\t\t<div class=\"lsc-sf-date lsc-ir-date\">Poster presented at 2025 Clinical Trials in Alzheimer's Disease (CTAD); San Diego, CA<br> Authors: Iaci JF, Grundman M, Hernandez NAS, et al.<\/div>\n\t\t\t<\/div>\t\t\t\n\t\t\t\t\t<div class='lsc-sf-item'>\n\t\t\t\t<div class=\"lsc-sf-date lsc-ir-date\">November 16, 2025 | <em>Manuscript<\/em><\/div>\n\t\t\t\t<div class=\"lsc-sf-title lsc-ir-title\"><a href=\"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/epdf\/10.1002\/alz.71004\" target=\"_blank\" class=\"lsc-sf-link\">Phase 2 study of zervimesine (CT1812) in participants with mild-to-moderate dementia with Lewy bodies (DLB)<\/a><\/div>\n\t\t\t\t<div class=\"lsc-sf-date lsc-ir-date\">Alzheimer\u2019s Dement. 2025; 21:e71004<br> Authors: Galvin JE, Tolea MI, Scharre DW, et al.<\/div>\n\t\t\t<\/div>\t\t\t\n\t\t\t\t\t<div class='lsc-sf-item'>\n\t\t\t\t<div class=\"lsc-sf-date lsc-ir-date\">July 27, 2025 | <em>Scientific Slides<\/em><\/div>\n\t\t\t\t<div class=\"lsc-sf-title lsc-ir-title\"><a href=\"https:\/\/cogrx.com\/wp-content\/uploads\/2025\/07\/Galvin-AAIC-2025-slides-FINAL-0729-Podium.pdf\" target=\"_blank\" class=\"lsc-sf-link\">Phase 2 Study of CT1812 in Mild-to-Moderate Dementia with Lewy Bodies<\/a><\/div>\n\t\t\t\t<div class=\"lsc-sf-date lsc-ir-date\">Slides presented at 2025 Alzheimer\u2019s Association International Conference (AAIC); Toronto, Ontario, Canada<br> Authors: Galvin JE, Hambe ME, Iaci JF, et al.<\/div>\n\t\t\t<\/div>\t\t\t\n\t\t\t\t\t<div class='lsc-sf-item'>\n\t\t\t\t<div class=\"lsc-sf-date lsc-ir-date\">July 27, 2025 | <em>Poster<\/em><\/div>\n\t\t\t\t<div class=\"lsc-sf-title lsc-ir-title\"><a href=\"https:\/\/cogrx.com\/wp-content\/uploads\/2025\/07\/Lizama-et-al-2025-AAIC-SHINE-CSF-Proteomics.pdf\" target=\"_blank\" class=\"lsc-sf-link\">Exploratory CSF Proteomic Analysis of a Pre-specified pTau217 Subgroup from the SHINE Clinical Trial Identifies Biomarkers Correlated with Cognitive Improvement<\/a><\/div>\n\t\t\t\t<div class=\"lsc-sf-date lsc-ir-date\">Poster presented at 2025 Alzheimer\u2019s Association International Conference (AAIC); Toronto, Ontario, Canada<br> Authors: Lizama BN, Pandey K, Cho E, et al<\/div>\n\t\t\t<\/div>\t\t\t\n\t\t\t\t\t<div class='lsc-sf-item'>\n\t\t\t\t<div class=\"lsc-sf-date lsc-ir-date\">July 27, 2025 | <em>Poster<\/em><\/div>\n\t\t\t\t<div class=\"lsc-sf-title lsc-ir-title\"><a href=\"https:\/\/cogrx.com\/wp-content\/uploads\/2025\/07\/Grundman-et-al-2025-AAIC-CT1812-benefits-p-tau217-subgroup-across-AD-spectrum.pdf\" target=\"_blank\" class=\"lsc-sf-link\">Zervimesine (CT1812) Treatment Benefits Patients with Lower Baseline Plasma p-tau217 Across the Mild-to-Moderate AD Spectrum<\/a><\/div>\n\t\t\t\t<div class=\"lsc-sf-date lsc-ir-date\">Poster presented at 2025 Alzheimer\u2019s Association International Conference (AAIC); Toronto, Ontario, Canada<br> Authors: Grundman M, Catalano S, Hamby ME, et al<\/div>\n\t\t\t<\/div>\t\t\t\n\t\t        <\/div><!-- lsc sf container close -->\n        <div class=\"pagination\">\n          <!-- pagenavi code -->\n\t\t<br \/><div class='wp-pagenavi' role='navigation'>\n<span aria-current='page' class='current'>1<\/span><a class=\"page larger\" title=\"Page 2\" href=\"https:\/\/cogrx.com\/pipeline\/publications\/?sf_paged=2\">2<\/a><a class=\"page larger\" title=\"Page 3\" href=\"https:\/\/cogrx.com\/pipeline\/publications\/?sf_paged=3\">3<\/a><a class=\"page larger\" title=\"Page 4\" href=\"https:\/\/cogrx.com\/pipeline\/publications\/?sf_paged=4\">4<\/a><a class=\"page larger\" title=\"Page 5\" href=\"https:\/\/cogrx.com\/pipeline\/publications\/?sf_paged=5\">5<\/a><span class='extend'>...<\/span><a class=\"nextpostslink\" rel=\"next\" aria-label=\"Next Page\" href=\"https:\/\/cogrx.com\/pipeline\/publications\/?sf_paged=2\">\u00bb<\/a>\n<\/div>\t    <\/div><!-- pagination close -->\n        <\/div><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-226effd elementor-widget elementor-widget-menu-anchor\" data-id=\"226effd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-menu-anchor\" id=\"industry-ad-pubs\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2c5d0a9 elementor-hidden-desktop elementor-hidden-tablet elementor-hidden-mobile elementor-widget elementor-widget-toggle\" data-id=\"2c5d0a9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-4651\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-4651\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-chevron-down\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-chevron-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Relevant Industry Publications: Alzheimer's Disease<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-4651\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-4651\"><p><span id=\"industry-ad-pubs\" style=\"font-weight: 600;\"> Foundational Principles of Neuroscience:<\/span><\/p><ul><li>Takeuchi T, Duszkiewicz AJ, et al. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24298167\" target=\"_blank\" rel=\"noopener\">The synaptic plasticity and memory hypothesis: encoding, storage and persistence.<\/a> Philos Trans R Soc Lond B Biol Sci. 2013 Dec 2; 369(1633)<\/li><li>Kandel ER. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11691980\" target=\"_blank\" rel=\"noopener\">The molecular biology of memory storage: a dialogue between genes and synapses.<\/a> Science. 2001 Nov 2;294(5544):1030-8<\/li><li>Bliss TV, Lomo T. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/4727084\" target=\"_blank\" rel=\"noopener\">Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path<\/a>. J Physiol. 1973 Jul; 232(2):331-56.<\/li><li>Ram\u00f3n y Cajal S <a href=\"https:\/\/www.nobelprize.org\/uploads\/2018\/06\/cajal-lecture.pdf\" target=\"_blank\" rel=\"noopener\">The structure and connexions of neurons<\/a> (Lecture delivered December 12, 1906). In: (eds) Nobel Lectures, Physiology or Medicine 1901\u20131921. Elsevier Publishing Company, Amsterdam-London-New York<\/li><\/ul><p><span style=\"font-weight: 600;\">Genetic Basis of Alzheimer&#8217;s Disease:<\/span><\/p><ul><li>Karch CM, Cruchaga C, et al. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24991952\" target=\"_blank\" rel=\"noopener\">Alzheimer\u2019s Disease Genetics: From the bench to the clinic. Neuron.<\/a> 2014 Jul 2; 83(1): 11\u201326<\/li><li>Tanzi, RE. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23028126\" target=\"_blank\" rel=\"noopener\">The Genetics of Alzheimer Disease.<\/a> Cold Spring Harb Perspect Med. 2012 Oct 1; 2(10)<\/li><\/ul><p><span style=\"font-weight: 600;\">Synapse Loss Correlates to Cognitive Deficit:<\/span><\/p><ul><li>de Wilde MC, et al. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26776762\" target=\"_blank\" rel=\"noopener\">Meta-analysis of synaptic pathology in Alzheimer\u2019s disease reveals selective molecular vesicular machinery vulnerability.<\/a> Alzheimers Dement. 2016 Jun;12(6):633-44<\/li><li>Scheff SW, et al. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17470753\" target=\"_blank\" rel=\"noopener\">Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment.<\/a> Neurology. 2007 May 1; 68(18):1501-8<\/li><li>Scheff SW, et al. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16289476\" target=\"_blank\" rel=\"noopener\">Hippocampal synaptic loss in early Alzheimer\u2019s disease and mild cognitive impairment.<\/a> Neurobiol Aging. 2006 Oct; 27(10):1372-84<\/li><li>DeKosky ST and Price DA. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/14643375\" target=\"_blank\" rel=\"noopener\">Synaptic pathology in Alzheimer\u2019s disease: a review of ultrastructural studies.<\/a> Neurobiol Aging. 2003 Dec; 24(8):1029-46<\/li><li>Selkoe DJ. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12399581\" target=\"_blank\" rel=\"noopener\">Alzheimer\u2019s disease is a synaptic failure.<\/a> Science. 2002; 298:789\u2013791<\/li><li>R\u00f6ssler M, et al. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11904756\" target=\"_blank\" rel=\"noopener\">Stage-dependent and sector-specific neuronal loss in hippocampus during Alzheimer\u2019s disease.<\/a> Acta Neuropathol. 2002 Apr; 103(4):363-9<\/li><li>DeKosky ST, Scheff SW, Styren SD. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9117556\" target=\"_blank\" rel=\"noopener\">Structural correlates of cognition in dementia: quantification and assessment of synapse change.<\/a> Neurodegeneration. 1996 Dec; 5(4):417-21<\/li><li>Lassmann H, Fischer P, Jellinger K. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8239314\" target=\"_blank\" rel=\"noopener\">Synaptic pathology of Alzheimer\u2019s disease.<\/a> Ann N Y Acad Sci. 1993 Sep 24;695:59-64<\/li><li>Terry RD, et al. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/1789684\" target=\"_blank\" rel=\"noopener\">Physical basis of cognitive alterations in Alzheimer\u2019s disease: synapse loss is the major correlate of cognitive impairment.<\/a> Ann Neurol. 1991;30:572\u2013580<\/li><li>DeKosky ST, Scheff SW.<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/2360787\" target=\"_blank\" rel=\"noopener\"> Synapse loss in frontal cortex biopsies in Alzheimer\u2019s disease: correlation with cognitive severity.<\/a> Annals of Neurology. 1990 May; 27(5):457-64<\/li><\/ul><p><span style=\"font-weight: 600;\">Monomers, Oligomers, Fibrils and Plaques &#8211; the A\u03b2 Equilibrium:<\/span><\/p><ul><li>Esparza TJ, Gangolli M, et al. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29979775\" target=\"_blank\" rel=\"noopener\">Soluble amyloid-beta buffering by plaques in Alzheimer disease dementia versus high-pathology controls.<\/a> PLoSOne. 2018 Jul 6; 13(7)<\/li><li>Brody DL, Jiang H, et al. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28818091\" target=\"_blank\" rel=\"noopener\">Non-canonical soluble amyloid-beta aggregates and plaque buffering: controversies and future directions for target discovery in Alzheimer\u2019s disease.<\/a> Alzheimers Res Ther. 2017 Aug 17; 9(1):62<\/li><li>van Maanen EM, van Steeg TJ, et al. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26826190\" target=\"_blank\" rel=\"noopener\">Systems Pharmacology Analysis of the Amyloid Cascade after \u03b2-Secretase Inhibition Enables the Identification of an A\u03b242 Oligomer Pool.<\/a> J Pharmacol Exp Ther. 2016 Apr; 357(1):205-16<\/li><\/ul><p><span style=\"font-weight: 600;\">A\u03b2 Accumulates and Self-Associates into Oligomers:<\/span><\/p><ul><li>Brinkmalm G, Hong W, et al.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31032851\" target=\"_blank\" rel=\"noopener\">Identification of neurotoxic cross-linked amyloid-\u03b2 dimers in the Alzheimer\u2019s brain<\/a>. Brain. 2019 May 1;142(5):1441-1457<\/li><li>Savioz A, Giannakopoulos P, et al.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27400224\" target=\"_blank\" rel=\"noopener\">A Study of A\u03b2 Oligomers in the Temporal Cortex and Cerebellum of Patients with Neuropathologically Confirmed Alzheimer\u2019s Disease Compared to Aged Controls.<\/a>\u00a0Neurodegener Dis. 2016; 16(5-6):398-406<\/li><li>Esparza TJ, Zhao H, et al.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23225543\" target=\"_blank\" rel=\"noopener\">Amyloid-\u03b2 oligomerization in Alzheimer dementia versus high-pathology controls.<\/a>\u00a0Ann Neurol. 2013 Jan; 73(1):104-19<\/li><li>Tomic JL, Pensalfini A, et al.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19523517\" target=\"_blank\" rel=\"noopener\">Soluble fibrillar oligomer levels are elevated in Alzheimer\u2019s disease brain and correlate with cognitive dysfunction.<\/a>\u00a0Neurobiol Dis. 2009 Sep; 35(3):352-8<\/li><\/ul><p><span style=\"font-weight: 600;\">A\u03b2 Oligomers Bind to a Receptor Complex on Synapses:<\/span><\/p><ul><li>Smith LM, Kostylev MA, et al.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30787106\" target=\"_blank\" rel=\"noopener\">Systematic and standardized comparison of reported amyloid-\u03b2 receptors for sufficiency, affinity, and Alzheimer\u2019s disease relevance<\/a>. J Biol Chem. 2019 Apr 12; 294(15):6042-6053<\/li><li>Zhao J, Li A, et al.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30240608\" target=\"_blank\" rel=\"noopener\">Soluble A\u03b2 Oligomers Impair Dipolar Heterodendritic Plasticity by Activation of mGluRin the Hippocampal CA1 Region<\/a>. iScience. 2018 Aug 31; 6:138-150<\/li><li>Smith LM, Strittmatter SM.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27940601\" target=\"_blank\" rel=\"noopener\">Binding Sites for Amyloid-\u03b2 Oligomers and Synaptic Toxicity<\/a>. Cold Spring Harb Perspect Med. 2017 May 1; 7(5)<\/li><\/ul><p><span style=\"font-weight: 600;\">Bound A\u03b2 Oligomers are Toxic to Synapses:<\/span><\/p><ul><li>Cline EN, Bicca MA, et al.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29843241\" target=\"_blank\" rel=\"noopener\">The Amyloid-\u03b2 Oligomer Hypothesis: Beginning of the Third Decade.<\/a>\u00a0J Alzheimers Dis. 2018; 64(s1):S567-S610<\/li><li>Selkoe DJ, Hardy J.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27025652\" target=\"_blank\" rel=\"noopener\">The Amyloid Hypothesis of Alzheimer\u2019s Disease at 25 Years.<\/a>\u00a0EMBO Molecular Medicine. 2016 Jun; 8(6):595-608<\/li><li>Spires-Jones TL, Hyman BT.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24853936\" target=\"_blank\" rel=\"noopener\">The intersection of amyloid beta and tau at synapses in Alzheimer\u2019s disease<\/a>. Neuron. 2014 May 21; 82(4):756-71<\/li><li>Mucke L, Selkoe DJ.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22762015\" target=\"_blank\" rel=\"noopener\">Neurotoxicity of Amyloid \u03b2-Protein: Synaptic and Network Dysfunction<\/a>. Cold Spring Harb Perspect Med. 2012 Jul; 2(7):a006338<\/li><li>Walsh DM, Klyubin I, et al.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11932745\" target=\"_blank\" rel=\"noopener\">Naturally secreted oligomers of amyloid \u03b2 protein potently inhibit hippocampal long-term potentiation<i> in vivo<\/i>.<\/a>\u00a0Nature. 2002 Apr 4; 416(6880):535-9<\/li><li>Lambert MP, Barlow AK, et al.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9600986\" target=\"_blank\" rel=\"noopener\">Diffusible, nonfibrillar ligands derived from A\u03b21\u201342 are potent central nervous system neurotoxins.\u00a0<\/a>Proc Natl Acad Sci USA. 1998 May 26; 95(11):6448-53<\/li><\/ul><p><span style=\"font-weight: 600;\">Sigma-2 Receptor Complex Biology and Role in Disease:<\/span><\/p><ul><li>Alon A, Schmidt HR, et al.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28559337\" target=\"_blank\" rel=\"noopener\">Identification of the gene that codes for the \u03c32 receptor.<\/a>\u00a0Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):7160-7165<\/li><li>Riad A, Zeng C, et al.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30443021\" target=\"_blank\" rel=\"noopener\">Sigma-2 Receptor\/TMEM97 and PGRMC-1 Increase the Rate of Internalization of LDL by LDL Receptor through the Formation of a Ternary Complex<\/a>. Sci Rep. 2018 Nov 15;8(1):16845<\/li><\/ul><p><span style=\"font-weight: 600;\">Biomarkers of Disease and Target Engagement:<\/span><\/p><ul><li>Schindler SE, Li Y, et al;\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30846386\" target=\"_blank\" rel=\"noopener\">Emerging cerebrospinal fluid biomarkers in autosomal dominant Alzheimer\u2019s disease<\/a>. Alzheimers Dement. 2019 May;15(5):655-665<\/li><li>Dhiman K, Blennow K, et al.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30770953\" target=\"_blank\" rel=\"noopener\">Cerebrospinal fluid biomarkers for understanding multiple aspects of Alzheimer\u2019s disease pathogenesis<\/a>. Cell Mol Life Sci. 2019 May;76(10):1833-1863<\/li><li>Chen MK, Mecca AP, et al.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30014145\" target=\"_blank\" rel=\"noopener\">Assessing Synaptic Density in Alzheimer Disease With Synaptic Vesicle Glycoprotein 2A Positron Emission Tomographic Imaging<\/a>. JAMA Neurol. 2018 Oct 1; 75(10):1215-1224<\/li><li>Mormino EC, Jagust WJ.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30014142\" target=\"_blank\" rel=\"noopener\">A New Tool for Clinical Neuroscience-Synaptic Imaging<\/a>. JAMA Neurol. 2018 Oct 1; 75(10):1181-1183<\/li><li>Toledo JB, Arnold M, et al.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28341160\" target=\"_blank\" rel=\"noopener\">Metabolic network failures in Alzheimer\u2019s disease: A biochemical road map<\/a>. Alzheimers Dement. 2017 Sep; 13(9):965-984<\/li><li>Russell CL, Mitra V, et al.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27636850\" target=\"_blank\" rel=\"noopener\">Comprehensive Quantitative Profiling of Tau and Phosphorylated Tau Peptides in Cerebrospinal Fluid by MassSpectrometry Provides New Biomarker Candidates<\/a>. J Alzheimers Dis. 2017; 55(1):303-313<\/li><li>\u00d6hrfelt A, Brinkmalm A, et al.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27716408\" target=\"_blank\" rel=\"noopener\">The Pre-Synaptic Vesicle Protein Synaptotagmin is a Novel Biomarker for Alzheimer\u2019s Disease<\/a>. Alzheimer\u2019s Research &amp; Therapy. 2016; Oct 3; 8(1):41<\/li><li>Janelidze S, Hertze J, et al.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26783546\" target=\"_blank\" rel=\"noopener\">Cerebrospinal Fluid Neurogranin and YKL-40 as Biomarkers of Alzheimer\u2019s Disease. Annals of Clinical and Translational Neurology<\/a>. 2015 Nov 20; 3(1):12-20<\/li><\/ul><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-4652\" class=\"elementor-tab-title\" data-tab=\"2\" role=\"button\" aria-controls=\"elementor-tab-content-4652\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-chevron-down\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-chevron-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Relevant Industry Publications: Dry AMD<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-4652\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"region\" aria-labelledby=\"elementor-tab-title-4652\"><p><span style=\"font-weight: 600;\"> AMD Rationale:<\/span><\/p><ul><li>Wang JH, Urrutia-Cabrera D, Mesa Mora S, Nguyen T, et al. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2020.07.10.198143v1\" target=\"_blank\" rel=\"noopener\">Functional study of the AMD-associated gene TMEM97 in retinal pigmented epithelium using CRISPR interference<\/a>.<br \/>bioRxiv 2020 July 10 doi:10.1101\/2020.07.10.198143<\/li><li>Wang s, Wang x, Cheng y, et al. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6556250\/\" target=\"_blank\" rel=\"noopener\">Autophagy Dysfunction, Cellular Senescence, and Abnormal Immune-Inflammatory Responses in AMD: From Mechanisms to Therapeutic Potential<\/a>. Oxid Med Cell Longev. 2019; 2019: 3632169<\/li><li>Mir SUR, Schwarze SR, Jin L, et al. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24113030\/\" target=\"_blank\" rel=\"noopener\">Progesterone receptor membrane component 1\/Sigma-2 receptor associates with MAP1LC3B and promotes autophagy<\/a>. Autophagy, 9:10, 1566-1578<\/li><li>Luibl V, Isas JM, Kayed R, et al. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1359048\/\" target=\"_blank\" rel=\"noopener\">Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers<\/a>. J Clin Invest. 2006; 116(2): 378-385<\/li><li>Lynn SA, Keeling E, Munday R, et al. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5436342\/\" target=\"_blank\" rel=\"noopener\">The complexities underlying age-related macular degeneration: could amyloid beta play an important role?<\/a>\u00a0Neural Regen Res. 2017; 12(4): 538-548<\/li><li>Keeling E, Chatelet DS, Johnston DA, et al. <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mnfr.201800951\" target=\"_blank\" rel=\"noopener\">Oxidative Stress and Dysfunctional Intracellular Traffic Linked to an Unhealthy Diet Results in Impaired Cargo Transport in the Retinal Pigment Epithelium (RPE)<\/a>. Mol Nutr Food Res. 2019; 63(15): e1800951<\/li><li>Ahmed IS, Rohe HJ, Twist KE, Craven RJ. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2915713\/\" target=\"_blank\" rel=\"noopener\">Pgrmc1 (progesterone receptor membrane component 1) associates with epidermal growth factor receptor and regulates erlotinib sensitivity<\/a>. J Biol Chem. 2010; 285(32): 24775-24782<\/li><li>Kabe Y, Handa H, Suematsu M. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6064819\/\" target=\"_blank\" rel=\"noopener\">Function and structural regulation of the carbon monoxide (CO)-responsive membrane protein PGRMC1<\/a>. J Clin Biochem Nutr. 2018; 63(1): 12-17.<\/li><li>Riad A, Zeng C, Weng CC, et al. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6238005\/\" target=\"_blank\" rel=\"noopener\">Sigma-2 Receptor\/TMEM97 and PGRMC-1 Increase the Rate of Internalization of LDL by LDL Receptor through the Formation of a Ternary Complex<\/a>. Sci Rep. 2018; 8(1):16845<\/li><li>van Leeuwen EM, Emri E, Merle BMJ, et al. <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1350946217301271?via%3Dihub\" target=\"_blank\" rel=\"noopener\">A new perspective on lipid research in age-related macular degeneration<\/a>. Prog Retin Eye Res. 2018; 67:56-86<\/li><li>Ahmed IS, Chamberlain C, Craven RJ. <a href=\"https:\/\/www.tandfonline.com\/doi\/abs\/10.1517\/17425255.2012.658367?journalCode=iemt20\" target=\"_blank\" rel=\"noopener\">S2R(Pgrmc1): the cytochrome-related sigma-2 receptor that regulates lipid and drug metabolism and hormone signaling<\/a>. Expert Opin Drug Metab Toxicol. 2012; 8(3): 361-370.<\/li><li>Sanchez-Pulido L, Ponting CP. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4263179\/\" target=\"_blank\" rel=\"noopener\">TM6SF2 and MAC30, new enzyme homologs in sterol metabolism and common metabolic disease<\/a>. Front Genet. 2014;5:439<\/li><\/ul><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Relevant Industry Publications: Alzheimer&#8217;s Disease Foundational Principles of Neuroscience: Takeuchi T, Duszkiewicz AJ, et al. The synaptic plasticity and memory hypothesis: encoding, storage and persistence. Philos Trans R Soc Lond B Biol Sci. 2013 Dec 2; 369(1633) Kandel ER. The molecular biology of memory storage: a dialogue between genes and synapses. Science. 2001 Nov 2;294(5544):1030-8 [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":0,"parent":5745,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_theme","meta":{"_acf_changed":false,"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"full-width-container","site-content-style":"unboxed","site-sidebar-style":"unboxed","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-12960","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/cogrx.com\/wp-json\/wp\/v2\/pages\/12960","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cogrx.com\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/cogrx.com\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/cogrx.com\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/cogrx.com\/wp-json\/wp\/v2\/comments?post=12960"}],"version-history":[{"count":0,"href":"https:\/\/cogrx.com\/wp-json\/wp\/v2\/pages\/12960\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/cogrx.com\/wp-json\/wp\/v2\/pages\/5745"}],"wp:attachment":[{"href":"https:\/\/cogrx.com\/wp-json\/wp\/v2\/media?parent=12960"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}